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Molecular mechanism of Translation initiation

Why Translation is important?

Regulation of protein synthesis is critical for various biological phenomena.

Gene expression control via translational regulation occurs in conditions with
nutrient deprivation and stress, development and differentiation, nervous system
function, aging and disease.  Translation is fundamentally regulated at
the initiation stage, rather than during elongation or termination, allowing rapid,
reversible and spatial control of gene expression.

1. Translation Initiation by mRNA looping


2. HCV IRES dependent translation under stress condition.


3. Translation Initiation mechanism study by Single Molecule Dynamics