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Eung-Sam Kim, Seonyoung Kim, Kwan Yong Choi and Ki-Ho Han
Micro-/Nanotechnology-based Isolation and Clinical Significance of Circulating Tumor Cells.
Biomedical Engineering Letters 2012 2(2):78-87


Eui Ho Kim, Jeremy A. Sullivan, Erin H. Plisch, Melba Marie Tejera, Anna Jatzek, Kwan Yong Choi and M. Suresh
Signal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation.
Journal of Immunology 2012 188:4305-4314


Kim ES, Kim JS, Lee Y, Choi KY, Park JW
Following the DNA Ligation of a Single Duplex Using Atomic Force Microscopy.
ACS Nano. 2012 in press


Yang JA, Kim ES, Kwon JH, Kim H, Shin JH, Yun SH, Choi KY, Hahn SK
Transdermal Delivery of Hyaluronic Acid - Human Growth Hormone Conjugate.
Biomaterials 2012 33(25):5947-54


Eung-Sam Kim, Chang-Kyoon Shim, Jae W. Lee, Joon Won Park and Kwan Yong Choi
Synergistic Effect of Orientation and Lateral Spacing of Protein G on an On-chip Immunoassay.
Analyst 2012 137(10):2421-30


Se Jin Im, Sang In Yang, Se Hwan Yang, Dong Hoon Choi, So Young Choi, Hea Sook Kim, Do Soo Jang, Kyeong Sik Jin, Yo-Kyung Chung, Seung-Hee Kim, Sang Hoon Paik, Yoo Chang Park, Moon Koo Chung, Yong Bum Kim, Kang-Hyun Han, Kwan Yong Choi, Young Chul Sung
Natural Form of Noncytolytic Flexible Human Fc as a Long-Acting Carrier of Agonistic Ligand, Erythropoietin.
Plos ONE 2011 6(9): e24574


Daekeun Lee, In-Gu Do, Kyusam Choi, Chang Ohk Sung, Kee-Taek Jang, Dongwook Choi, Jin Seok Heo, Seoung Ho Choi, Jongmin Kim, Jin Young Park, Hyung Jin Cha, Jae-Won Joh, Kwan Yong Choi and Dae Shick Kim
The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas.
Modern Pathology 2011 25(1):131-9


Eung-Sam Kim, Chang Ok Kim, Joon Won Park and Kwan Yong Choi
Detection of central single-nucleotide mismatches in short duplex DNAs on hyper-branched amine surfaces.
BioChip Journal 2011 5(2):137-144


Cha HJ, Kim J, Hong SM, Hong SJ, Park JH, Kim ES, Wang HJ, Choi YJ, Do IG, Joh JW, Kim DS, Choi KY
Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma.
Annals of Surgical Oncol 2011 in press

Kim ES, Hong BJ, Park CW, Kim Y, Park JW, Choi KY
Effects of lateral spacing on enzymatic on-chip DNA polymerization.
Biosensors and Bioelectronics 2011 26:2566-2573


Hong BH, Oh SJ, Hong BJ, Jang DS, Yun YS, Park JW, Choi KY
Oligonucleotide microarrays with high discriminating power for the detection of single nucleotide variations in the p53 gene.
Mol Cells 2010 30(6):575-9


Yoon JH, Kim ES, Lee SJ, Park CW, Cha HJ, Hong BH, Choi KY
Apoptosis-related mRNA expression profiles of ovarian cancer cell lines following cisplatin treatment.
J Gynecol Oncol 2010 21(4):255-261


Kwon JH, Kim J, Park JY, Hong SM, Park CW, Hong SJ, Park SY, Choi YJ, Do I, Joh JW, Kim DS, Choi KY
Overexpression of HMGB2 is associated with tumor aggressiveness and prognosis of hepatocellular carcinoma.
Clin Cancer Res. 2010 16(22):5511-5521


Park SH, Doh J, Park SI, Lim JY, Kim SM, Youn JI, Jin HT, Seo SH, Song MY, Sung SY, Kim M, Hwang SJ, Choi JM, Lee SK, Lee HY, Lim CL, Chung YJ, Yang D, Kim HN, Lee ZH, Choi KY, Jeun SS, Sung YC
Branched oligomerization of cell-permeable peptides markedly enhances the transduction efficiency of adenovirus into mesenchymal stem cells.
Gene Ther. 2010 17(8):1052-61


Yang SY, Yang JA, Kim ES, Jeon G, Oh EJ, Choi KY, Hahn SK, Kim JK
Single-file diffusion of protein drugs through cylindrical nanochannels.
ACS Nano. 2010 27;4(7):3817-22


Kim J, Hong SJ, Park JY, Park JH, Yu YS, Park SY, Lim EK, Choi KY, Lee EK, Paik SS, Lee KG, Wang HJ, Do IG, Joh JW, Kim DS
Epithelial-mesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma.
Cancer Sci. 2010 101(6):1521-8


Lee D, Kwon JH, Kim EH, Kim ES, Choi KY
HMGB2 stabilizes p53 by interfering with E6/E6AP-mediated p53 degradation in human papillomavirus-positive HeLa cells.
Cancer Letters 2010 292(1):125-32


Hong SJ, Kim J, Park JH, Lim EK, Kim J, Choi YJ, Gu HD, Kim SW, Choi KY, Joh JW, Kim DS
Proteomic Profiling of Human Hepatocellular Carcinoma Tissues by Two-Dimensional Electrophoresis and Mass Spectrometry.
Biochip Journal 2009 3(3) 237-248


Lee D, Park CW, Paik SR, Choi KY
The modification of alpha-synuclein by dicarbonyl compounds inhibits its fibril-forming process.
Biochin Biophys Acta. 2009 1794(3) 421-430


Yoo HJ, Yun BR, Kwon JH, Ahn HS, Seol MA, Lee MJ, Yu GR, Yu HC, Hong B, Choi K, Kim DG
Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells.
Exp Mol Med. 2009 28;41(2):102-15


Kim TG, Cha HJ, Lee HJ, Heo SD, Choi KY, Ku JK, Ban C.
Structural insights of the nucleotide dependent conformational changes of Thermotoga maritima MutL using small-angle X-ray scattering analysis.
J Biochem. 2009 145(2)199-206


Lee HJ, Jang do S, Cha HJ, Moon HS, Hong BH, Choi KY, Lee HC.
NMR studies on the equilibrium unfolding of ketosteroid isomerase by urea.
J Biochem. 2008 144(2):215-21


Lee HJ, Yoon YJ, Jang do S, Kim C, Cha HJ, Hong BH, Choi KY, Lee HC.
15N NMR relaxation studies of Y14F mutant of ketosteroid isomerase: the influence of mutation on backbone mobility.
J Biochem. 2008 144(2):159-66


Lee HJ, Moon HS, Jang do S, Cha HJ, Hong BH, Choi KY and Lee HC
Probing the equilibrium unfolding of ketosteroid isomerase through xenon-perturbed(1)H-15N multidimensional NMR spectroscopy
J Biomol NMR. 2008 40(1):65-70


Seong Kyu Song, Zina Moldoveanu, Huan H. Nguyen, Eui-Ho Kim, Kwan Yong Choi, Jong Bae Kim and Jiri Mestecky
Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice
Vaccine 2007 25(34) 6359-6366


Yun YS, Lee W, Shin S, Oh BH, Choi KY.
Arg-158 is critical in both binding the substrate and stabilizing the transition-state oxyanion for the enzymatic reaction of malonamidase E2.
J Biol Chem. 2006 Dec 29;281(52):40057-64. Epub 2006 Oct 31.


Jang DS, Lee HJ, Lee B, Hong BH, Cha HJ, Yoon J, Lim K, Yoon YJ, Kim J, Ree M, Lee HC, and Choi KY.
Detection of an intermediate during the unfolding process of the dimeric ketosteroid isomerase.
FEBS Lett. (2006) 580 4166-4177


Yun YS, Nam GH, Kim YG, Oh BH, and Choi.KY.
Small Exterior Hydrophobic Cluster Contributes to Conformational Stability and Steroid Binding in Ketosteroid Isomerase from Pseudomonas putida Biotype B.
FEBS J. (2005) 272, 1999-2011


Oh SJ, Ju J, Kim BC, Ko E, Hong BJ, Park JG, Park JW and Choi KY.
DNA microarrays on a dendron-modified surface improve significantly the detection of single nucleotide variations in the p53 gene
Nucleic Acids Res. (2005) 33(10), e90


Lee D, Paik SR, and Choi KY.
beta-Synuclein exhibits chaperone activity more efficiently than alpha-synuclein.
FEBS Lett. (2004) 576(1-2), 256-60.


Jang DS, Cha HJ, Cha SS, Hong BH, Ha NC, Lee JY, Oh BH, Lee HS, and Choi KY.
Structural double-mutant cycle analysis of a hydrogen bond network in ketosteroid isomerase from Pseudomonas putida biotype B.
Biochem J. (2004) 382 (Pt 3), 967-973


Nam GH, Cha SS, Yun YS, Oh YH, Hong BH, Lee HS, and Choi KY.
The conserved cis-Pro39 residue plays a crucial role in the proper positioning of the catalytic base Asp38 in ketosteroid isomerase from Comamonas testosteroni.
Biochem. J. (2003) 375 (Pt 2), 297-305


Nam GH, Kim DH, Ha NC, Jang DS, Yun YS, Hong BH, Oh BH, and Choi KY.
Contribution of conserved amino acids at the dimeric interface to the conformational stability and the structural integrity of the active site in ketosteroid isomerase from Pseudomonas putida biotype B. J. Biochem. (2003) 134,101-110.


Yun YS, Lee TH, Nam GH, Jang DS, Shin S, Oh BH, and Choi KY.
Origin of the different pH-activity profile in two homologous ketosteroid isomerases.
J. Biol. Chem. (2003) 278, 28229-28236.


Shin S, Yun YS, Koo HM, Kim YS, Choi KY, and Oh BH.
Characterization of a novel Ser-cisSer-Lys catalytic triad in comparison with the classical Ser-His-Asp triad.
J. Biol. Chem. (2003) 278, 24937-24943.


Han J. S., Kim, D. H. and Choi, K. Y.
Potyvirus NIa proteinase. Handbook of Proteolytic Enzymes, Chap. Arcademic Press (2003)


Nam G. H. and Choi K. Y.
Association of human tumor necrosis factor-related apoptosis inducing ligand with membrane upon acidification.
Eur. J. Biochem. 2002 Nov;269(21):5280-7.


Chang Y. T., Choi G. , Bae Y. S. ,Burdett M. ,Moon H. S. ,Lee J. W. ,Gray S.N. ,Schultz G. P. ,Meijer L. ,Chung S. K. , Choi K. Y. , Suh P. G., Ryu S. H.
Purine-based inhibitors of inositol-1,4,5,-trisphosphate-3-kinase.
ChemBioChem 2002 Sep 2;3(9):897-901.


Yun S. , Jang D. S. , Choi G. , Kim K. S. , Choi K. Y. , Lee H. C.
Trifluoroethanol increases the stability of D5-3-ketosteroid isomerase. 15N NMR relaxation studies.
J. Biol. Chem. 2002 Jun 28;277(26):23414-9.


Kang B. H. , Ko E. , Kwon O. , Choi K. Y.
The structure of pro-caspase-6 is similar to that of active mature caspase-6. Biochem.
J. 2002 Jun 15;364(Pt 3):629-34.


Cho J. H. , Kim D. H. , Chung S. J. , Ha N. C. , Oh B. H. , Choi K. Y.
Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A.
Bioorg. Med. Chem. 2002 Jun;10(6):2015-22.


Ha S. J. , Chang J. , Song M. K. ,Suh Y. S. , Jin H. T. , Lee C. H. ,Nam G. H. ,Choi G. ,Choi K. Y. ,Lee S. H.,Kim W. B. ,Sung Y. C.
Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T lymphocyte responses for DNA immunization.
Nat. Biotechnol. 2002 Apr;20(4):381-6.


Ha N. C. ,Choi G. ,Choi K. Y. ,Oh B. H.Structure and enzymology of Delta(5)-3-ketosteroid isomerase. Curr. Opin. Struct. Biol. 2001 Dec;11(6):674-8. Review.


Nam G. H. , Jang D. S. , Cha S. S., Lee T. H. , Kim D. H. , Hong B. H. , Yun Y. S. , Oh B. H. , Choi K. Y.
Maintenance of alpha-helical structures by phenyl rings in the active-site tyrosine triad contributes to catalysis and stability of ketosteroid isomerase from Pseudomonas putida biotype B.
Biochemistry 2001 Nov 13;40(45):13529-37.


Cho J. H. , Kim D. H. , Lee K. J. , Kim D. H. , Choi K. Y.
The role of Tyr248 probed by mutant bovine carboxypeptidase A: insight into the catalytic mechanism of carboxypeptidase A.
Biochemistry 2001 Aug 28;40(34):10197-203.


Choi G. , Ha N. C. , Kim M. S. , Hong B. H. , Oh B. H. , Choi K. Y.
Pseudoreversion of the catalytic activity of Y14F by the additional substitution(s) of tyrosine with phenylalanine in the hydrogen bond network of delta 5-3-ketosteroid isomerase from Pseudomonas putida biotype B.
Biochemistry 2001 Jun 12;40(23):6828-35.


Yun S. , Jang D. S. , Kim D. H. , Choi K. Y. , Lee H. C.
15N NMR relaxation studies of backbone dynamics in free and steroid-bound Delta 5-3-ketosteroid isomerase from Pseudomonas testosteroni.
Biochemistry 2001 Apr 3;40(13):3967-73.


Kim D. H. , Jang D. S. , Nam G. H. , Choi K. Y.
Folding Mechanism of Ketosteroid Isomerase from Comamonas testosteroni.
Biochemistry 2001 Apr 24;40(16):5011-7.


Kim D. H. , Nam G. H. , Jang D. S. , Yun S. , Choi G. , Lee H. C. , Choi K. Y.
Roles of dimerization in folding and stability of ketosteroid isomerase from Pseudomonas putida biotype B.
Protein Sci. 2001 Apr;10(4):741-52


Kim DH, Jang DS, Nam GH, Yun S, Cho JH, Choi G, Lee HC, and K.Y.Choi,
Equilibrium and Kinetic Analysis of Folding of Ketosteroid Isomerase from Comamonas testosteroni.
Biochemistry 39, 2000


Hwang DC, Kim DH, Lee JS, Kang BH, Han J, Kim W, Song BD, Choi KY.
Characterization of active-site residues of the NIa protease from tobacco vein mottling virus.
Mol Cells. 2000 Oct 31;10(5):505-11.


G. Choi, N. Ha, S. W. Kim, D. Kim, S. Park, B. Oh, and K.Y.Choi,
Asp-99 Donates a Hydrogen Bond Not to Tyr-14 but to the Steroid Directly in the Catalytic Mechanism of Delta5-3 Ketosteroid,Biochemistry 39, 2000.


Kim D, Kang BH, Han JS, Choi KY.
Temperature and salt effects on proteolytic function of turnip mosaic potyvirus nuclear inclusion protein a exhibiting a low-temperature optimum activity.
Biochim Biophys Acta. 2000 Jul 14;1480(1-2):29-40.


Lee H, Mok KH, Muhandiram R, Park KH, Suk JE, Kim DH, Chang J, Sung YC, Choi KY, Han KH.
Local structural elements in the mostly unstructured transcriptional activation domain of human p53.
J Biol Chem. 2000 Jul 6 [epub ahead of print


Hwang DC, Kim DH, Kang BH, Song BD, Choi KY.
Molecular cloning, expression, and purification of nuclear inclusion A protease from tobacco vein mottling virus.
Mol Cells. 2000 Apr 30;10(2):148-55.


Ha NC, Oh BC, Shin S, Kim HJ, Oh TK, Kim YO, Choi KY, Oh BH.
Crystal structures of a novel, thermostable phytase in partially and fully calcium-loaded states
Nat Struct Biol. 2000 Feb;7(2):147-53.


Yoon HY, Hwang DC, Choi KY, Song BD.
Proteolytic processing of oligopeptides containing the target sequences by the recombinant tobacco vein mottling virus NIa proteinase.
Mol Cells. 2000 Apr 30;10(2):213-9.


Kim DH, Jang DS, Nam GH, Choi G, Kim JS, Ha NC, Kim MS, Oh BH, Choi KY.
Contribution of the hydrogen-bond network involving a tyrosine triad in the active site to the structure and function of a highly proficient ketosteroid isomerase from Pseudomonas putida biotype B.
Biochemistry. 2000 Apr 25;39(16):4581-9.


Yoon HY, Choi KY, Song BD.
Fluorometric assay of turnip mosaic virus NIa protease.
Anal Biochem. 2000 Jan 15;277(2):228-31.


Cho HS, Ha NC, Choi G, Kim HJ, Lee D, Oh KS, Kim KS, Lee W, Choi KY, Oh BH.
Crystal structure of delta(5)-3-ketosteroid isomerase from Pseudomonas testosteroni in complex with equilenin settles the correct hydrogen bonding scheme for transition state stabilization.
J Biol Chem. 1999 Nov 12;274(46):32863-8.


Kim DH, Nam GH, Jang DS, Choi G, Joo S, Kim JS, Oh BH, Choi KY.
Roles of active site aromatic residues in catalysis by ketosteroid isomerase from Pseudomonas putida biotype B.
Biochemistry. 1999 Oct 19;38(42):13810-9.


Kim JS, Cha SS, Kim HJ, Kim TJ, Ha NC, Oh ST, Cho HS, Cho MJ, Kim MJ, Lee HS, Kim JW, Choi KY, Park KH, Oh BH.
Crystal structure of a maltogenic amylase provides insights into a catalytic versatility.
J Biol Chem. 1999 Sep 10;274(37):26279-86.


Jun K, Choi G, Yang SG, Choi KY, Kim H, Chan GC, Storm DR, Albert C, Mayr GW, Lee CJ, Shin HS.
Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice.
Learn Mem. 1998 Sep-Oct;5(4-5):317-30.


Choi KY, Hahm KS, Rhee SK, Han MH.
An overview of biotechnology in Korea.
Trends Biotechnol. 1999 Mar;17(3):95-101.


Cha SS, Shin HC, Choi KY, Oh BH.
Expression, purification and crystallization of recombinant human TRAIL.
Acta Crystallogr D Biol Crystallogr. 1999 May;55(5):1101-4.


Cho HS, Choi G, Choi KY, Oh BH.
Crystal structure and enzyme mechanism of Delta 5-3-ketosteroid isomerase from Pseudomonas testosteroni.
Biochemistry. 1998 Jun 9;37(23):8325-30.


Kim DH, Han JS, Lew J, Kim SS, Kang BH, Hwang DC, Jang DS, Kim W, Song BD, Choi KY.
Effects of mutations in the C-terminal region of NIa protease on cis-cleavage between NIa and NIb.
Virology. 1998 Feb 1;241(1):94-100.


Kim SW, Cha SS, Cho HS, Kim JS, Ha NC, Cho MJ, Joo S, Kim KK, Choi KY, Oh BH.
High-resolution crystal structures of delta5-3-ketosteroid isomerase with and without a reaction intermediate analogue.
Biochemistry. 1997 Nov 18;36(46):14030-6.


Kim SW, Joo S, Choi G, Cho HS, Oh BH, Choi KY.
Mutational analysis of the three cysteines and active-site aspartic acid 103 of ketosteroid isomerase from Pseudomonas putida biotype B.
J Bacteriol. 1997 Dec;179(24):7742-7.


Kim DH, Hwang DC, Kang BH, Lew J, Han J, Song BD, Choi KY.
Effects of internal cleavages and mutations in the C-terminal region of NIa protease of turnip mosaic potyvirus on the catalytic activity.


Kim DH, Hwang DC, Kang BH, Lew J, Choi KY.
Characterization of Nla protease from turnip mosaic potyvirus exhibiting a low-temperature optimum catalytic activity.
Virology. 1996 Jul 1;221(1):245-9.