home sbp logo top_2depth_menu_bg postech 학과 contact us English

Research Area

cancer survival

mTOR pathway

cancer survival
M ammalian t arget o f r apamycin ( mTOR )
mTOR is well-conserved 289 kDa PI3K-related kinase (PIKK) → Ser, Thr kinase activity
mTOR pathway is critically involved in tumor growth and protein translation
mTOR Complex 1 (mTORC1) is composed of mTOR, regulatory associated protein of mTOR (Raptor), mammalian LST8/G-protein β-subunit like protein (mLST8/GβL) and the recently identified partner PRAS40.
mTOR Complex 2 (mTORC2) is composed of mTOR, rapamycin-insensitive companion of mTOR (Rictor), GβL, and mammalian stress-activated protein kinase interacting protein 1 (mSIN1).
The raptor-mTOR pathway regulates cell growth (accumulation of cell mass) through S6K1 and 4E-BP1 as well as unknown effectors. It responds to nutrients and growth factors in part through the upstream regulators TSC1/2 and rheb.
The rapamycin-insensitive rictor-mTOR pathway regulates Akt/PKB, PKC alpha, Rho.Rac to control cell survival, proliferation, metabolism and the cytoskeleton.
mTOR is related to some human disease including diabetes, obesity, cardiovascular diseases, neurological disorder, and cancer
The mTOR pathway is also upregulated in many human cancers and oncogenic transformation might sensitize cells to TOR inhibitors. TOR therefore represents a novel therapeutic target (anti-proliferative effect). → Rapamycin and its analogues are highly specific inhibitors of mTOR and are now in Phase I-III oncology clinical trials

The role of autophagy in cancer

The role of autophagy in cancer

The role of autophagy in cancer
Autophagy : 'Auto'(Self) + 'Phagy'(Eating)
One of two degradation mechanism in eukaryotic cells
Autophagy is a ubiquitous process in eukaryotic cells that results in the breakdown of cytoplasm within the lysosome in response to stress conditions and that provides the cell with "energy" and "building blocks".

Conflicting effects of autophagy on cancer

Conflicting effects of autophagy on cancer

Levine, Nature (2007)

Dramatic increase in autophagy research

Dramatic increase in autophagy research