postech wcu

FACULTY

Biotechnology

Biotechnology
Prof. Seung-Jae Lee님의 사진입니다.
Prof. Seung-Jae Lee
E-Mail : seungjaelee@postech.ac.kr
Position : Professor
Tel. : +82-54-279-2351, Lab: +82-54-279-8066
Laboratory : Aging molecule genetics Lab
Office : Life Science Bldg. #216
CAREER
- Postdoctoral fellow, Department of Biochemistry and Biophysics, Laboratory of Dr. Cynthia Kenyon University of California at San Francisco, San Francisco, CA
- Postgraduate research, Department of Biological Chemistry, Laboratory of Dr. Craig Montell, Johns Hopkins University School of Medicine, Baltimore, MD (2003-2004)

MAJOR AWARDS
- Postdoctoral fellowship from American Heart Association (2008-Present)
- Ellison Medical Foundation Fellow of the Life Sciences Research Foundation (2005-2008)

ACTIVITIES
- Postdoctoral research with Dr. Cynthia Kenyon, University of California at San Francisco, San Francisco, CA (2004-Present)
* Investigated mechanisms by which thermosensation influences the longevity response to temperature in C. elegans.
* Determined how glucose-enriched diet affects the lifespan of C. elegans by using a combination of molecular genetics, microarray analysis/bioinformatics and cell biology.
* Demonstrated that FOXO-insulin-FOXO signaling coordinates the rate of aging among the different tissues.

RESEARCH INTERESTS
C elegance genetic screening and drug testing

SELECTED PUBLICATIONS
- Lee, S.J., and Kenyon, C. (2009) Regulation of longevity response to temperature by hermosensory neurons in Caenorhabditis elegans. Curr. Biol. (in press)
- Murphy C.T.*, Lee S.J.*, and Kenyon C. (2007) Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 104: 19046-19050 (* equal contribution)
- Lee S.J., and Montell C. (2004). Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Curr. Biol. 14: 2076-2085 (Featured Article)
- Lee S.J., Xu H., and Montell C. (2004). Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Proc. Natl. Acad. Sci. USA 101: 11874-11879.
- Lee S.J., and Montell C. (2004). Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron 43: 95-103. (Commented in Faculty of 1000 and in a Preview in the same issue of Neuron)
- Lee S.J., Xu H., Kang L., Amzel L.M., and Montell C. (2003). Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron 39: 121-132. (Commented in Faculty of 1000, in a Dispatch in Current Biology 2003 13: R775-R777 and in a Perspective in Science STKE, 2003, Issue 204, p. pe43)