sbc_logo            The S tructural B iology of C ancer LabThe S tructural B iology of C ancer Lab

                     A Research Laboratory for Molecular Biology of Cancer
                     in the Department of Life Science at the Pohang University of Science and Technology (POSTECH)



Selected Publications


Dynamic assembly of Hda and the sliding clamp in the regulation of replication licensing

Jin S. Kim Michael T. Nanfara Sundari Chodavarapu Kyeong S. Jin Vignesh M. P. Babu Mohamed A. GhazyScisung Chung Jon M. Kaguni Mark D. Sutton Yunje Cho

Nucleic Acids Res. (2017) Feb 7. doi: 10.1093/nar/gkx081. [Epub ahead of print]


Eukaryotic Rad50 functions as a rod-shaped dimer

Young Bong Park*, Marcel Hohl*, Michał Padjasek, Eunyoung Jeong, Kyeong Sik Jin, Artur Krężel, John H J Petrini, Yunje Cho (* equal contribution)

Nat Struct Mol Biol (2017) Mar;24(3):248-257


ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex

Yaqi Liu*, Sihyun Sung*, Youngran Kim*, Fuyang Li, Gwanghyun Gwon, Aera Jo, Ae‐Kyoung Kim, Taeyoon Kim, Ok‐kyu Song, Sang Eun Lee, Yunje Cho (* equal contribution)

The EMBO Journal (2016) Apr 1;35(7):743-58



Crystal structure of the Rad3/XPD regulatory domain of Ssl1/p44

Jin Seok Kim*, Charlotte Saint-André*, Hye Seong Lim, Cheol-Sang Hwang, Jean Marc Egly, Yunje Cho (* equal contribution)

J Biol Chem (2015) Mar 27;290(13):8321-30



Crystal structure of a Fanconi   anemia-associated nuclease homolog bound to 5’ flap DNA: Basis of interstrand crosslink repair by FAN1

Gwang Hyeon Gwon*,Youngran Kim*,Yaqi Liu*,Adam T. Watson, Aera Jo,Thomas J. Etheridge, Fenghua Yuan, Yanbin Zhang,YoungChang Kim, Anthony M. Carr, Yunje Cho. (* equal contribution)

Genes & Dev. (2014)



Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation

Yaoyao Fu*, Youngran Kim*, Kyeong Sik Jin, Hyun Sook Kim, Jong Hyun Kim, DongMing Wang, Minyoung Park, Chang Hwa Jo, Nam Hoon Kwon, Doyeun Kim, Myung Hee Kim, Young Ho Jeon, Kwang Yeon Hwang, Sunghoon Kim, Yunje Cho. (* equal contribution)

Proc Natl Acad Sci U S A. (2014)

 

 

An Ankyrin Repeat Domain of AKR2 Drives Chloroplast Targeting through Coincident Binding of Two Chloroplast Lipids

Dae Heon Kim, Mi-Jeong Park, Gwang Hyeon Gwon, Antonina Silkov, Zheng-Yi Xu, Eun Chan Yang, Seohyeon Song, Kyungyoung Song, Younghyun Kim, Hwan Su Yoon, Barry Honig, Wonhwa Cho, Yunje Cho, Inhwan Hwang.

Dev Cell. (2014) 30: 598-609

 

 

DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.

Sihyun Sung*, Fuyang Li*, Young Bong Park, Jin Seok Kim, Ae‐Kyoung Kim, Ok‐kyu Song, Jiae Kim, Jun Che, Sang Eun Lee, Yunje Cho. (* equal contribution)

The EMBO Journal (2014)

 

 

Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates

Gwang Hyeon Gwon, Aera Jo, Kyuwon Baek, Kyeong Sik Jin, Yaoyao Fu, Jong-Bong Lee,YoungChang Kim, Yunje Cho.

The EMBO Journal (2014) 33: 1061–1072


                       

Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations
Young Bong Park, Jina Chae, Young Chang Kim, Yunje Cho.

Structure 19(2011) : 1591-1602

 

Sup1



Crystal structure of the NurA-dAMP-Mn2+ complex
Jina Chae, Young Chang Kim, Yunje Cho.

Nucleic Acids Research(2011) :1-13

 

 

Sup1
Sup2

 

Crystal structure of the Mre11-Rad50-ATP{gamma}S Complex: understanding the interplay between Mre11 and Rad50
Lim HS*, Kim JS*, Park YB, Gwon GH, Cho Y. (* equal contribution) 

Genes Dev (2011) 25(10) : 1091-104


Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors.
BI. Khayrutdinov, WJ Bae, YM Yun, JH Lee, Takashi Tsuyama, JJ Kim, Eunha Hwang, KS Ryu, HK Cheong, CJ Cheong, JS Ko, Takemi Enomoto, P. Andrew Karplus, Peter Guntert, Shusuke Tada, YH Jeon and Y Cho 
PROTEIN SCIENCE (2009) 18(11) : 2252-64


Crystal stucture of the human rad9-hus1-rad1 clamp
Sohn SY, Cho Y.   J Mol Biol (2009) 390 : 490-502


Crystal structure of the eIF4A-PDCD4 complex
J. H. Chang,  Y. H. Cho,  S. Y. Sohn,  J. M. Choi,  A. Kim,  S. K. Jang and Y. Cho   Proc Natl Acad Sci USA  (2009) 106 : 3148-3153

                       

Crystal structure of the Mus81-Eme1 complex            
J. H. Chang,  J. J. Kim,  J. M. Choi,  J. H. Lee and Y. Cho  Genes & Dev. (2008) 22: 1093-1106

                       

Crystal structure of human DGCR8 core             
S. Y. Sohn,  W. J. Bae,  J. J. Kim,  K. H. Yeom, V. N. Kim and Y. Cho   Nat. Struct. Mol. Biol. (2007) 14(9):847-53

 

Crystal structure of human GINS complex
J. M. Choi,  H. S. Lim,  J. J. Kim, O. K. Song, and Y. Cho   Genes & Dev. (2007)

                       

Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein            
J. M. Choi,  S. Y. Kang, W. J. Bae, K. S. Jin, M. Ree, Y. Cho    J.Biol.Chem (2007) 282:9941-51

 

Structure of a peptide:N-glycanase-Rad23 complex: Insight into the deglycosylation for denatured glycoproteins
J. H. Lee,  J. M. Choi , C. Lee , K. J. Yi , Y. Cho   Proc Natl Acad Sci USA  (2005) 102 : 9144-9149

 

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
C. Lee,  B.S. Hong, J. M. Choi, Y. Kim,S. Watanabe, Y. Ishimi, T.Enomoto, S. Tada,Y.C. Kim and Y. Cho   Nature (2004) 430: 913-7