글번호
5118057
일 자
16.03.22
조회수
132
글쓴이
김은아
제목 : 2016-03-18 저널 Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes. (유진배)
 2016 Jan 15;351(6270). pii: aad4939. doi: 10.1126/science.aad4939. Epub 2016 Jan 14.

Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes.

Abstract

To investigate gene specificity at the level of translation in both the human genome and viruses, we devised a high-throughput bicistronic assay to quantify cap-independent translation. We uncovered thousands of novel cap-independent translation sequences, and we provide insights on the landscape of translational regulation in both humans and viruses. We find extensive translational elements in the 3' untranslated region of human transcripts and the polyprotein region of uncapped RNA viruses. Through the characterization of regulatory elements underlying cap-independent translation activity, we identify potential mechanisms of secondary structure, short sequence motif, and base pairing with the 18S ribosomal RNA (rRNA). Furthermore, we systematically map the 18S rRNA regions for which reverse complementarity enhances translation. Thus, we make available insights into the mechanisms of translational control in humans and viruses.

Copyright © 2016, American Association for the Advancement of Science.

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