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5856213
일 자
16.10.07
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98
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김은아
제목 : 2016-10-07 Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. (권오성)
2016 Sep 30;353(6307):1549-1552.

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Abstract

Cyclin A2 activates the cyclin-dependent kinases Cdk1 and Cdk2 and is expressed at elevated levels from S phase until early mitosis. We found that mutant mice that cannot elevate cyclin A2 are chromosomally unstable and tumor-prone. Underlying the chromosomal instability is a failure to up-regulate the meiotic recombination 11 (Mre11) nuclease in S phase, which leads to impaired resolution of stalled replication forks, insufficient repair of double-stranded DNA breaks, and improper segregation of sister chromosomes. Unexpectedly, cyclin A2 controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation. These data reveal cyclin A2 as a mechanistically diverse regulator of DNA replication combining multifaceted kinase-dependent functions with a kinase-independent, RNA binding-dependent role that ensures adequate repair of common replication errors.

Copyright © 2016, American Association for the Advancement of Science.

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